In accordance with the reversibility feature of CryoTherapy, target cardiac cells are cooled from body temperature to temperatures between, approximately, +37°C and +5°C. When subjected to temperatures in this range, a hypothermic effect is seen whereby electrical activity slows down or is temporarily interrupted. The cell and organelle membranes of the cardiomyocytes begin to undergo the first of a series of transitions. Membranes become less fluid, their ion pumps begin to lose transport capability, which is observable electrophysiologically. Upon rewarming, normal cell function is restored – also observable electrophysiologically.