Electrophysiology

Treating arrhythmias with cryotherapy

CryoCath catheters look and handle like heat-based catheters, but do not destroy tissue in the same manner. They remove heat from target tissue, slowing cellular activity. Both the amount of heat and the speed at which it is removed can be controlled, allowing for a transient or permanent electrical effect in target cells.

The mechanisms of CryoTherapy are largely seen at the cellular level, where sub-zero temperatures induce both intracellular and extracellular ice crystal formation. The extracellular fibrous matrix, largely composed of anhydrous components containing components such as elastin and collagen, remains largely unaffected by ice crystal formation. Consequently, tissue CryoAblation can be performed without damage to the underlying structure of the heart.

Safety and practicality are important features associated with CryoTherapy in the treatment of cardiac arrhythmias. CryoTherapy offers electrophysiologists the ability to test potential ablation sites accurately by inducing a reversible electrical and thermal effect. CryoTherapy procedures also offer increased site precision through CryoAdhesion. It produces well-demarcated cryolesions that heal quickly. Tissue immediately adjacent to a cryolesion demonstrates normal electrical activation. There is also a reduced risk of perforation with CryoTherapy. Pre-clinical studies have demonstrated minimal endothelial disruption and thrombus.